There are a few nuances making it difficult to simply give flat recommendations for all who live with the A1298C MTHFR mutation. I don’t mean to belabor that point but it is after all a book while this is an article. Again, I address this heavily in the book, Dirty Genes. That is well beyond the scope of this article. There are certain dietary, lifestyle and supplemental recommendations that help reduce the effects of the A1298C MTHFR mutation. Possible conditions associated with A1298C MTHFR mutations: decreased epinephrine and norepinephrine.Possible signs associated with A1298C MTHFR Mutations: Possible symptoms associated with A1298C MTHFR mutations: Then it will provide you methods to clean it up. There is a MTHFR Quiz in the book, Dirty Genes, which will show you if your MTHFR gene is acting dirty or not. I will add to it as I think of more (or you inform me of ones that I have omitted). Keep in mind this is not a comprehensive list. I am going to list possible symptoms, signs and conditions associated with MTHFR mutations. Once you understand the biochemical effects the MTHFR mutation causes, it becomes easy to identify possible problems. If your BH4 cycle is not working properly due to a MTHFR mutation, you are definitely going to be expressing some symptoms either mentally, emotionally or physically – or – all together. The BH4 cycle is absolutely critical for these various functions:ĭoes one see only elevated homocysteine in those with the C677T MTHFR mutation and only mood disorders in those with A1298C MTHFR? Why? Because the MTHFR 677 variant is more severe than the 1298. In fact, lower tetrahydrabiopterin levels are likely found more frequently in those with the 677 variant compared to the 1298. There is not one study that shows biopterin recycling is limited to those with A1298C compared to those with C677T. Some people say that BH4 regeneration is only done by those having the MTHFR A1298C snp – and not those with the MTHFR C677T snps. Regardless of which snp you have, either the 677 or 1298, the MTHFR enzyme’s end product, methylfolate, supports two major pathways: BH4 and Methylation.īH4 regeneration is supported by methylfolate and SAM. I know many doctors evaluate homocysteine only when it comes to MTHFR mutations. Learn how to clean up your Dirty MTHFR gene by reading Dirty Genes Obviously, if one leads a lifestyle which is unhealthy (smoking, high stress, toxic exposures) and consumes an unhealthy diet (refined carbs, processed meats, saturated fats), then having a heterozygous A1298C mutation may contribute to cardiovascular disease, depression, fibromyalgia and others.Īnyone with or without any MTHFR mutations can still have what I call a ‘Dirty MTHFR’ gene. My current stance on the heterozygous MTHFR A1298C mutation is that it is very common and does not seem to pose too much concern unless there are other methylation or cytochrome mutations present. Compound heterozygous A1298C + C677T MTHFR mutation (like me). The MTHFR A1298C mutation may affect you if you are either: I’d like to prove them wrong – at least for the symptoms which do correlate with the A1298C MTHFR mutation. Symptoms exist and doctors are saying there is no correlation between the MTHFR A1298C mutation and your symptoms – right? Research seems to ignore it almost completely while the C677T MTHFR mutation gets all the attention and glory.įor those who have the A1298C MTHFR mutation, this is frustrating. There is little known about the A1298C MTHFR mutation.
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